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Karl Gibson
Karl Gibson PhD CChem FRSC LinkedIn
Publications
Karl obtained his degree and PhD in Chemistry from the University of Cambridge. He then spent 5 years as a medicinal chemist at Merck's Neuroscience Research Centre, working on CNS targets. In 2002 Karl moved to Pfizer where he has led medicinal chemistry teams across the Pain, Urology and Infectious Disease therapeutic areas. As a research project leader, he has led multi-disciplinary project teams, delivering candidates to the clinic. His most recent role was as head of exploratory Pain chemistry where he specialised in target validation approaches, HTS triage, hit finding and delivering optimal programs to find clinical candidates rapidly. He has experience of ion channels, GPCRs, kinases, enzymes, PPIs and nuclear receptors. He has managed academic collaborations and large teams of outsourced chemistry. Outside Pfizer, Karl has taught medicinal chemistry at Imperial College and Oxford University and sits on the Biological & Medicinal Chemistry Section committee of the Royal Society of Chemistry.

Gavin Whitlock
Gavin Whitlock PhD CChem FRSC LinkedIn
Publications
Gavin obtained his degree and PhD in Chemistry from the University of Nottingham.  He then carried out postdoctoral research at the University of Oxford and The California Institute of Technology.  Gavin joined Pfizer as a medicinal chemist in 1997 where over the past 15 years he has led medicinal chemistry design teams working across multiple disease areas (Infectious Diseases, Genitourinary, Tissue Repair, Allergy & Respiratory and Neglected Diseases) and gene families (kinases, GPCRs, metalloproteinases and monoamine transporters).  This has resulted in the delivery of 6 candidate molecules to the clinic.  His areas of expertise encompass an understanding of the molecular properties that are important for oral, CNS, topical and inhaled routes of administration and in silico assessment of toxicology risk to drive low attrition.  Additionally he has experience of leading integrated drug discovery teams of chemistry, biology, ADME, pharmaceutical science and drug safety colleagues.

James Mills
James Mills PhD FRSC LinkedIn
Publications
James obtained his degree and PhD in the Pharmacology Department at the University of Cambridge. His post-doctoral research was as a part of the TeknoMed project, a collaboration with Imperial College and Rhone-Poulenc-Rorer in which novel computational algorithms were applied to the design of compounds for proprietary projects. He joined Pfizer in 1999 as a Computational Chemist and spent 12 years supporting over 100 projects across multiple disease areas, writing and applying novel algorithms to support all stages of the drug discovery process, including target analysis, HTS triage, lead and candidate molecule design. His areas of expertise include SAR analysis and visualisation, virtual screening, analysis of molecular interactions, ligand superposition and structure-based drug design. In addition to his role at Sandexis, James is the founder of Bespoke Comp Chem Ltd. and a part-time Research Fellow at the Cambridge Crystallographic Data Centre.

Paul's picture
Paul Glossop BSc CChem FRSC LinkedIn
Publications
Paul graduated from the University of Nottingham with a BSc in Chemistry. He joined Pfizer as an Organic Chemist in 1993, moving into a Medicinal Chemistry role in 2000. He has extensive experience in the Allergy and Respiratory field, where he was involved in the delivery of a number of clinical candidates, two of which achieved a positive proof-of-concept. He has also worked in Genitourinary, Sexual Health and Tissue Repair, and has expertise in the design of compounds for oral, topical and inhaled administration against a range of targets, including GPCRs, kinases, other enzymes, ion channels, transporters and nuclear receptors. He was the recipient of the ACS Technical Achievement in Organic Chemistry Award in 2010. Between 2011 and 2013, he worked as a medical writer at ApotheCom ScopeMedical, a global medical communications agency, where his responsibilities included the preparation of peer-reviewed manuscripts, slide presentations, product information leaflets and advisory board reports.



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 Sandexis Medicinal Chemistry Ltd 2015
Company No. 07767700
Postal address: Innovation House, Discovery Park, Ramsgate Road, Sandwich, Kent, CT13 9ND, UK
Business registered address: 45 Queen Street, Deal, Kent, CT14 6EY, UK
e-mail: info@sandexis.co.uk